The major goal of this project is to develop a large cohort in East Africa to evaluate the epidemiology and response to antiretroviral therapy among HIV-infected individuals in resource-limited settings. Data from East Africa are subsequently shared with the larger IeDEA network in 6 other regions worldwide. In addition, we are implementing a teledermatology system of surveillance in the Kenyan and Ugandan sites of IeDEA and are specifically studying outcomes and metrics through implementation science.